Ushering in a new era of medical imaging

New horizons for molecular imaging

Molecular imaging relies on administration of compounds (radiopharmaceuticals) that emit radiation in order to image biological function in vivo.

These radiopharmaceuticals contain a radioactive isotope, most frequently fluorine-18 in the case of PET, that decays and generates radiation detectable by a scanner.

Molecular imaging diagram

Our patented fluorine-18 radiolabelling method enables the ultra-efficient production of fluorine-18 containing HetSiFA™ compositions for PET scans.

These HetSiFA™ radiopharmaceutical compositions contain a novel class of stabilized Si–F bond that result in superior radiolabeling characteristics.

HetSiFA (tm)

Catalyze a better diagnostic

We can efficiently attach fluorine-18 to bioactive materials.

Molecules used in State of the Art
Comparison Factors Standard 18F Moiety
Bond type/strategy C-F bond
Manufacturing Challenging; often impractical for large and/or complex molecules
Literature Many reports
Radiolabeling time Typically >20 min
Radiosynthesis time Typically 1-3 hours
Radiochemical yield Highly variable (often <50%); acknowledged reproducibility issues
HPLC purification? Yes
Metals required for synthesis? Typically
Personnel Generally trained chemists
Synthesis temperature up to 150℃
Precursor loading 15,000-60,000 nmol
Fuzionaire HetSiFAs
Comparison Factors Fuzionaire Dx HetSiFAs™
Bond type/strategy C-Si-F bond
Manufacturing Facile using Fuzionaire alkali metal catalysis
Literature Novel compositions and methods; patents granted and pending
Radiolabeling time Seconds
Radiosynthesis time <10 minutes
Radiochemical yield >90% (facile, highly reproducible)
HPLC purification? No
Metals required for synthesis? No
Personnel Accessible to medical technicians
Synthesis temperature Typically 23℃
Precursor loading ≤50 nmol
Abstract symbol

Based on our core chemistry

These advancements are made possible with Fuzionaire’s core chemistry.

With our roots in a Caltech Nobel Laureate’s lab, we are exploring and developing the breakthrough in alkali metal catalysis featured in the film Element 19.

This breakthrough enables a new branch of catalysis that is based on Earth-abundant metals like potassium and sodium.

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Unlocking the periodic table

Molecule symbol


Earth-abundant metals like potassium and sodium are approximately 25,000,000x more abundant than precious metals.


The way in which we make and break bonds can be 10,000x less expensive than other methods.


Our chemistry enables entirely novel processes that are unlocking new possibilities in molecular science.

Get in touch

If you are interested in learning more about our radiolabeling platform, we want to hear from you.